(2012). On Human Kinds and Role Models: A Critical Discussion about the African American Male Teacher. Educational Studies: Vol. 48, Black Teachers Theorizing, pp. 296-315.

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

In chapter 1 of Reason, Truth, and History, Hilary Putnam argues from some plausible assumptions about the nature of reference to the conclusion that it is not possible that all sentient creatures are brains in a vat. If this argument is successful, it seemingly refutes an updated form of Cartesian skepticism concerning knowledge of physical objects. In this paper, I will state what I take to be the most promising interpretation of Putnam's argument. My reconstructed argument differs from an argument (...) strongly suggested by Putnam's text. I will show that the latter argument obviously does not work. The more promising argument which I reconstruct on behalf of Putnam raises some interesting questions about the relation between the contents of one's beliefs and one's environment and about how this relation affects the evaluation of anti-skeptical arguments. I conclude that my reconstructed argument ultimately fails as a response to Cartesian skepticism: the argument engenders a skepticism about knowledge of meaning, or propositional content, which undercuts its anti-skeptical force. (shrink)

It seems that, whereas a person's death needn't be a bad thing for him, it can be. In some circumstances, death isn't a "bad thing" or an "evil" for a person. For instance, if a person has a terminal and very painful disease, he might rationally regard his own death as a good thing for him, or at least, he may regard it as something whose prospective occurrence shouldn't be regretted. But the attitude of a "normal" and healthy human being (...) - adult or child - toward the prospect of his death is different; it is not unreasonable in certain cases to regard one's own death as a bad thing for oneself. If this is so, then the question arises as to why death is bad, in those cases in which it is bad. (shrink)

In The Conscious Mind, D. Chalmers appeals to his semantic framework in order to show that conceivability, as employed in his "zombie" argument for dualism , is sufficient for genuine possibility. I criticize this attempt.

In this introduction to the special issue of Theoretical Medicine and Bioethics on the topic of personal identity and bioethics, I provide a background for the topic and then discuss the contributions in the special issue by Eric Olson, Marya Schechtman, Tim Campbell and Jeff McMahan, James Delaney and David Hershenov, and David DeGrazia.

A Kantian transcendental argument is an argument which purports to show that the existence of physical objects of a certain general character is a condition for the possibility of self-conscious experience. Both the Transcendental Deduction and the Refutation of Idealism satisfy this characterization. But we have seen that even a successful Kantian transcendental argument would be somewhat disappointing. Even though such an argument would refute the extreme Cartesian skepticism about the very existence of physical objects, it would not certify any (...) of one's claims to know facts about particular physical objects: it would not refute the weaker skeptical position I have sketched.5 How- ever, it would clearly be of great interest if one could show that the existence of physical objects is a condition for the possibility of self- conscious experience. Accordingly, I would like to investigate some problems surrounding the construction of Kantian transcendental arguments. (shrink)

In part I of the present work, I used the term 'Kantian transcendental argument' to refer to any argument which purports to establish that the existence of outer objects is a logically necessary condition for the possibility of self-conscious experience. In this second part, then, I examine Kantian transcendental arguments which proceed from the premise that one is the subject of widely construed self-conscious experience.

Gary Ebbs has argued that skepticism regarding knowledge of the contents of one's own mental states cannot even be coherently formulated. This articles is a reply to that argument.

This is a response to an argument (by Michael McKinsey) purporting to show that anti-individualism is trivially true. I show that this argument rests upon a misconception of the basic claim of anti-individualism.

Volume 19, Issue 12, December 2019, Page 35-37.

Michael McKinsey has argued that content externalism has the absurd consequence that one can know a priori that water exists. Richard W. Miller responds that when a prioricity is properly understood, McKinsey's argument should not be seen as a _reductio of externalism. This paper disputes Miller's understanding of a prioricity.

This paper describes the implications of the transition from Ontology conceived as fundamental metaphysical logos to ontologies construed as postmodern historical applications of this, and then, finally, to Trans-Ontology as the ultimate, futuristic innovation of Transhumanism. If modernity counts as the key shift that has occurred in our living and understanding of the world since the dawn of history, postmodernism seems to be the record of a transition from the absolute Grand Narratives of modernity to a scenario consisting of polycentric, (...) equally justified narratives. Thus, the historical failure of the old Ontology, in the form of monarchy, absolutism, monotheistic religions, Eurocentrism, and nationalism, entails the plurality of approaches and diversity of flexible transformations of ontologies. Yet such a purportedly liberating evolution is encountered en route to the likewise postmodern trans-humanist impulse that aims at a complete transformation of the traditional human essence by means of a theurgist, miraculous, Trans-Theological technology. The latter’s goal is to normalize the arrival of a paradoxically innovative universe, where transhuman beings will rebuild the world, and re-essentialize it. Ultimately, this universal integralism will be based on an ever-growing ludic character, coupled with a mathematically scheduled playfulness, aiming at a transformed, fully integrated and manageable entity. (shrink)

We highlight the various domains of the flavivirus virulence factor NS1 and speculate on potential implications of the NS1 3D structure in understanding its role in flavivirus pathogenesis. Flavivirus non‐structural protein 1 (NS1) is a virulence factor with dual functions in genome replication and immune evasion. Crystal structures of NS1, combined with reconstructions from electron microscopy (EM), provide insight into the architecture of dimeric NS1 on cell membranes and the assembly of a secreted hexameric NS1‐lipid complex found in patient sera. (...) Three structural domains of NS1 likely have distinct roles in membrane association, replication complex assembly, and immune system avoidance. A conserved hydrophobic inner face is sequestered either on the membrane or in the interior of the secreted hexamer and contains regions implicated in viral replication. The exposed variable outer face is presented to cellular and secreted components of the immune system in infected patients and contains candidate regions for immune system modulation. We anticipate that knowledge of the distinct NS1 domains and assembly will lead to advances in elucidating virus‐host interactions mediated through NS1 and in dissecting the role of NS1 in viral genome replication. (shrink)

In "Of Personal Identity,", Hume attempts to explain how one arrives at the fiction of a substantial self which retains its numerical identity through time. In "Of Scepticism with Regard to the Senses," Hume offers a similar explanation of the origin of another fiction - that of objects which enjoy a continued and distinct existence. In this paper, I will argue that his pair of parallel explanations does not jointly account for the pair of fictions to be explained.